I had originally discovered this article Talk about blue in the face...Extraordinary story of Appalachia's 'Blue Family' on the UK's Daily Mail site. After searching for more information tho, I came across the following story which gives a much richer history than the Daily Mail article.

THE BLUE PEOPLE OF TROUBLESOME CREEK: The story of an Appalachian malady, an inquisitive doctor, and a paradoxical cure;by Cathy Trost, ©Science 82, November, 1982:

Six generations after a French orpha...

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